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Article

MglA/SspA complex interactions are modulated by inorganic polyphosphate.

PloS one - 1 Jan 2013

Wrench Algevis P, Gardner Christopher L, Siegel Sara D, Pagliai Fernando A, Malekiha Mahsa, Gonzalez Claudio F, Lorca Graciela L

Abstract excerpt

The transcription factors MglA and SspA of Francisella tularensis form a heterodimer complex and interact with the RNA polymerase to regulate the expression of the Francisella pathogenicity island (FPI) genes. These genes are essential for this pathogen's virulence and survival within host cells. Our goal was to determine if an intracellular metabolite modulate these protein/protein interactions. In this study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24116108
DOI: 10.1371/journal.pone.0076428
PMCID: PMC3792966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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