Article
Coval: improving alignment quality and variant calling accuracy for next-generation sequencing data.
PloS one - 1 Jan 2013
Kosugi Shunichi, Natsume Satoshi, Yoshida Kentaro, MacLean Daniel, Cano Liliana, Kamoun Sophien, Terauchi Ryohei
Abstract excerpt
Accurate identification of DNA polymorphisms using next-generation sequencing technology is challenging because of a high rate of sequencing error and incorrect mapping of reads to reference genomes. Currently available short read aligners and DNA variant callers suffer from these problems. We developed the Coval software to improve the quality of short read alignments. Coval is designed to minimize the incidence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.