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Article

Genome assembly quality: assessment and improvement using the neutral indel model.

Genome research - 1 May 2010

Meader Stephen, Hillier LaDeana W, Locke Devin, Ponting Chris P, Lunter Gerton

Abstract excerpt

We describe a statistical and comparative-genomic approach for quantifying error rates of genome sequence assemblies. The method exploits not substitutions but the pattern of insertions and deletions (indels) in genome-scale alignments for closely related species. Using two- or three-way alignments, the approach estimates the amount of aligned sequence containing clusters of nucleotides that were wrongly inserted...

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Identifiers

PMID: 20305016
DOI: 10.1101/gr.096966.109
PMCID: PMC2860169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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