Article
TP53 codon 72 polymorphism in oral squamous cell carcinoma.
Anticancer research - 1 Jan 2000
Drummond Sérgio Neves, De Marco Luiz, Pordeus Isabela De Almeida, Barbosa Alvimar Afonso, Gomez Ricardo Santiago
Abstract excerpt
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein. The relationship between human cancer susceptibility and p53...
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