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Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells

24 Sept 2013

Abstract excerpt

Aggressive dissemination and metastasis of pancreatic ductal adenocarcinoma (PDAC) results in poor prognosis and marked lethality. Rho monomeric G protein levels are increased in pancreatic cancer tissue. As the mechanisms underlying PDAC malignancy are little understood, we investigated the role for cAMP in regulating monomeric G protein regulated invasion and migration of pancreatic cancer cells. Treatment of...

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PMID: 24115212
DOI: 10.1002/mc.22091

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