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Article

G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells.

Oncogene - 6 Jun 2002

Régnauld Karine, Nguyen Quang-Dé, Vakaet Luc, Bruyneel Erik, Launay Jean-Marie, Endo Takeshi, Mareel Marc, Gespach Christian, Emami Shahin

Abstract excerpt

The heterotrimeric G-protein subunits Galpha and Gbetagamma are involved in cellular transformation and tumor development. Here, we report the expression of Galpha(olf) in human digestive and urogenital epithelial cells using RT-PCR and Western blot. When the constitutively activated form of Galpha(olf)Q214L (AGalpha(olf)) was stably transfected in canine kidney MDCKts.src and human colonic HCT-8/S11 epithelial...

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PMID: 12037684
DOI: 10.1038/sj.onc.1205498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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