Article
In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.
Pharmacogenetics - 1 Dec 2001
Lin Y S, Lockwood G F, Graham M A, Brian W R, Loi C M, Dobrinska M R, Shen D D, Watkins P B, Wilkinson G R, Kharasch E D, Thummel K E
Abstract excerpt
We investigated whether a single plasma midazolam concentration could serve as an accurate predictor of total midazolam clearance, an established in-vivo probe measure of cytochrome P450 3A (CYP3A) activity. In a retrospective analysis of data from 224 healthy volunteers, non-compartmental pharmacokinetic parameters were estimated from plasma concentration-time curves following intravenous (IV) and/or oral...
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