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Article

Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2005

Rawden H C, Carlile D J, Tindall A, Hallifax D, Galetin A, Ito K, Houston J B

Abstract excerpt

The intrinsic clearances (CLint) of midazolam, triazolam, diazepam, nordiazepam, flunitrazepam and alprazolam were determined from two liver banks (n=21) by formation kinetics of ten metabolites. A literature-collated database of in vivo CLint values (811 subjects) was used to assess predictions...

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Share to Benzodiazepines
Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Metabolic Clearance Rate

Share to Microsomes, Liver

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Source

Identifiers

PMID: 16192111
DOI: 10.1080/00498250500162870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16192111-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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