Article
Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2005
Rawden H C, Carlile D J, Tindall A, Hallifax D, Galetin A, Ito K, Houston J B
Abstract excerpt
The intrinsic clearances (CLint) of midazolam, triazolam, diazepam, nordiazepam, flunitrazepam and alprazolam were determined from two liver banks (n=21) by formation kinetics of ten metabolites. A literature-collated database of in vivo CLint values (811 subjects) was used to assess predictions and variability. The in vivo clearance of six benzodiazepines was generally underpredicted by in vitro data and the...
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