Article
Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment.
Biogerontology - 1 Dec 2013
Fiol-deRoque Maria A, Gutierrez-Lanza Raquel, Terés Silvia, Torres Manuel, Barceló Pere, Rial Rubén V, Verkhratsky Alexei, Escribá Pablo V, Busquets Xavier, Rodríguez José J
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. In the last years, abnormalities of lipid metabolism and in particular of docosahexaenoic acid (DHA) have been recently linked with the development of the disease. According to the recent studies showing how hydroxylation of fatty acids enhances their biological activity, here we show that chronic treatment with a hydroxylated...
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