Article
Dehydroevodiamine•HCl Protects Against Memory Impairment and Cerebral Amyloid-β Production in Tg2576 Mice by Acting as a β-Secretase Inhibitor.
CNS & neurological disorders drug targets - 1 Jan 2016
Shin Ki Young, Noh Su-Jin, Park Cheol Hyoung, Jeong Yun Ha, Chang Keun-A, Yoo Jakyung, Kim Hee Jin, Ha Sungji, Kim Hye-Sun, Park Hyun-Ju, Lee Jun-Ho, Moon Cheil, Suh Yoo-Hun
Abstract excerpt
We previously demonstrated that dehydroevodiamine•HCl (DHED), which was purified from Evodia rutaecarpa Bentham (Rutaceae), has beneficial effects on memory impairment and neuronal damage in three disease models. To investigate the preventive action of DHED in Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by memory decline, amyloid-β (Aβ) protein-containing neuritic plaques and...
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