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Article

Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.

Blood - 5 Dec 2013

Bulut Gamze B, Sulahian Rita, Yao Huiyu, Huang Lily Jun-shen

Abstract excerpt

Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in the overproduction of erythrocytes in primary familial and congenital polycythemia (PFCP). Here we have identified a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24113870
DOI: 10.1182/blood-2013-05-506212
PMCID: PMC3854114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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