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Article

Dynamic ligand modulation of EPO receptor pools, and dysregulation by polycythemia-associated EPOR alleles.

PloS one - 1 Jan 2012

Singh Seema, Verma Rakesh, Pradeep Anamika, Leu Karen, Mortensen R Bruce, Young Peter R, Oyasu Miho, Schatz Peter J, Green Jennifer M, Wojchowski Don M

Abstract excerpt

Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for erythropoiesis; can modulate non-erythroid target tissues; and have been reported to affect the progression of certain cancers. Basic studies of EPOR expression and trafficking, however, have been hindered by low-level EPOR occurrence, and the limited specificity of anti-EPOR antibodies. Consequently, these aspects of EPOR biology are not...

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Source

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Identifiers

PMID: 22253704
DOI: 10.1371/journal.pone.0029064
PMCID: PMC3257245

Genes

EPOR
EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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