Article
Initial exploration of oral pazopanib in healthy participants and patients with age-related macular degeneration.
JAMA ophthalmology - 1 Dec 2013
McLaughlin Megan M, Paglione Marcella G, Slakter Jason, Tolentino Michael, Ye Li, Xu Chun-Fang, Suttle A Benjamin, Kim Robert Y
Abstract excerpt
IMPORTANCE: Neovascular age-related macular degeneration (AMD) is managed with intravitreal anti-vascular endothelial growth factor therapy; however, the burden of care is high and alternate approaches could be beneficial. OBJECTIVE To identify an acceptable dose of oral pazopanib for investigation in AMD. DESIGN, SETTING, AND PARTICIPANTS: Fourteen-day, placebo-controlled, dose-rising study in 72 healthy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.