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Article

Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degeneration.

Pharmacogenomics - 1 Jul 2012

Agosta Elisa, Lazzeri Stefano, Orlandi Paola, Figus Michele, Fioravanti Anna, Di Desidero Teresa, Sartini Maria Sole, Nardi Marco, Danesi Romano, Bocci Guido

Abstract excerpt

Age-related macular degeneration (AMD), the most common age-related disease causing irreversible visual loss in industrialized countries, is a complex and multifactorial illness. Researchers have found components of the complement alternative pathway inside drusen and Bruch's membrane of AMD patients, underlying a possible important role of complement factor H in the pathogenesis of AMD. The neovascular (wet) AMD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22838951
DOI: 10.2217/pgs.12.77

Genes

CFH

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