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Article

Pharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-related macular degeneration in the IVAN Study.

Ophthalmology - 1 Dec 2013

Lotery Andrew J, Gibson Jane, Cree Angela J, Downes Susan M, Harding Simon P, Rogers Chris A, Reeves Barnaby C, Ennis Sarah, Chakravarthy Usha

Abstract excerpt

PURPOSE: To determine if prespecified genetic polymorphisms influence responsiveness to vascular endothelial growth factor (VEGF) inhibition in neovascular age-related macular degeneration (nAMD). The objectives were to replicate 3 reported pharmacogenetic associations of response in nAMD and to test for novel associations. DESIGN: Cohort study, combining information about patients' genotypes with information...

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Source

Identifiers

PMID: 24070809
DOI: 10.1016/j.ophtha.2013.07.046

Genes

ARMS2
EPAS1
HTRA1
CFH
FZD4

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