Article
Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.
Molecular vision - 1 Jan 2012
Wang Vinson M, Rosen Richard B, Meyerle Catherine B, Kurup Shree K, Ardeljan Daniel, Agron Elvira, Tai Katy, Pomykala Matthew, Chew Emily Y, Chan Chi-Chao, Tuo Jingsheng
Abstract excerpt
PURPOSE: The use of anti-vascular endothelial growth factor (anti-VEGF) therapy, with drugs such as ranibizumab and bevacizumab, to treat neovascular age-related macular degeneration (nAMD) produces an effective but widely variable response. Identifying markers that predict differentiated response could serve as a valuable assay in developing more personalized medicine. This study aimed to identify single...
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