Article
Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2002
Jain Anjali, Lam Amanda, Vivanco Igor, Carey Michael F, Reiter Robert E
Abstract excerpt
Prostate stem cell antigen (PSCA) is emerging as an important diagnostic marker and therapeutic target in prostate cancer. Previous studies indicated that PSCA was directly regulated by androgens, but the mechanism has not been elucidated. Here we describe the identification of a compact cell-specific and androgen-responsive enhancer between 2.7 and 3 kb upstream of the transcription start site. The enhancer...
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