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Article

ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer

15 Feb 2013

Abstract excerpt

Fusion of the androgen receptor-regulated (AR-regulated) TMPRSS2 gene with ERG in prostate cancer (PCa) causes androgen-stimulated overexpression of ERG, an ETS transcription factor, but critical downstream effectors of ERG-mediating PCa development remain to be established. Expression of the SOX9 transcription factor correlated with TMPRSS2:ERG fusion in 3 independent PCa cohorts, and ERG-dependent expression of...

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PMID: 23426182
DOI: 10.1172/jci66666

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