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Article

Gene polymorphisms predicting response to hydroxyurea treatment in Bahraini patients with sickle cell disease.

Expert review of hematology - 1 Nov 2025

Alshaikh Fatimah S, Deifalla Abdelhalim, Sequeira Reginald P, Woodman Alexander

Abstract excerpt

BACKGROUND: This study investigated the association between response to hydroxyurea (HU) treatment and fetal hemoglobin (HbF), and the prevalence of mutations that regulate HbF synthesis, drug transport and biotransformation in sickle cell disease (SCD) patients. RESEARCH DESIGN AND METHODS: Study included n = 390 Bahrainis with a history of sickle cell crises. Responders (n = 127; 68%) were patients achieving...

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Topics

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Share to Anemia, Sickle Cell
Share to Child
Share to Fetal Hemoglobin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Hydroxyurea

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 40781956
DOI: 10.1080/17474086.2025.2546575

Genes

CYP2C19
ARG2
HBS1L
MYB
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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