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Doublesex- and Mab-3-Related Transcription Factor-1 Repression of Aromatase Transcription, a Possible Mechanism Favoring the Male Pathway in Tilapia

7 Jan 2010

Abstract excerpt

Doublesex- and Mab-3-related transcription factor-1 (Dmrt1) is an important transcription factor implicated in early testicular differentiation in vertebrates, but its target genes are largely unknown. In the Nile tilapia, estrogen is the natural inducer of ovarian differentiation. Our recent studies have shown that Forkhead-l2 up-regulated transcription of the Cyp19a1a gene (aromatase) in the gonads in a...

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Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Sexual Differentiation and Disorders
Sperm and Testicular Function

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20056824
DOI: 10.1210/en.2009-0999

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Doublesex- and Mab-3-Related Transcription Factor-1 Repression of Aromatase Transcription, a Possible Mechanism Favoring the Male Pathway in TilapiaPMID 20056824Read ↗

dmrt1 Is Responsible for Androgen-Induced Masculinization in Nile Tilapia.Semantic proximity Read ↗

Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.Semantic proximity Read ↗

Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs.Semantic proximity Read ↗

Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.Semantic proximity Read ↗

Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapiaSemantic proximity Read ↗

<i>gsdf</i> is a downstream gene of <i>dmrt1</i> that functions in the male sex determination pathway of the Nile tilapiaSemantic proximity Read ↗

Dmrt1 directly regulates the transcription of the testis-biased Sox9b gene in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

Mutation ofcyp19a1bresults in sterile males due to efferent duct obstruction in Nile tilapiaSemantic proximity Read ↗

Dietary aromatase inhibitor treatment converts XY gsdf homozygous mutants to sub-fertile male in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

Cyp17a1 is Required for Female Sex Determination and Male Fertility by Regulating Sex Steroid Biosynthesis in FishSemantic proximity Read ↗

Haploinsufficiency of SF-1 Causes Female to Male Sex Reversal in Nile Tilapia, Oreochromis niloticusSemantic proximity Read ↗

Homozygous Mutation of gsdf Causes Infertility in Female Nile Tilapia (Oreochromis niloticus).Semantic proximity Read ↗

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