Article
Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability.
Molecular systems biology - 8 Oct 2013
Fehrmann Steffen, Bottin-Duplus Hélène, Leonidou Andri, Mollereau Esther, Barthelaix Audrey, Wei Wu, Steinmetz Lars M, Yvert Gaël
Abstract excerpt
Living systems may have evolved probabilistic bet hedging strategies that generate cell-to-cell phenotypic diversity in anticipation of environmental catastrophes, as opposed to adaptation via a deterministic response to environmental changes. Evolution of bet hedging assumes that genotypes segregating in natural populations modulate the level of intraclonal diversity, which so far has largely remained...
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