Article

Metformin modulates autophagy in heterozygous and CRISPR-edited <i>TSC2</i> primary fibroblasts

2026-08-11

Abstract excerpt

<h4>Background</h4> Tuberous Sclerosis Complex (TSC) is a genetic disorder caused by variants in TSC1 or TSC2, leading to mTORC1 hyperactivation and autophagy suppression. Although TSC tumorigenesis typically follows a “two-hit” model, the role of TSC2 haploinsufficiency in autophagy regulation remains unclear. We evaluated autophagy markers in haploinsufficient and gene-edited TSC2 primary cells and investigated...

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Literature Corpus work: 12e670c9-68d0-52a0-bd8a-d0518c7773fd
DOI: 10.64898/2026.08.11.743350

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