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Article

Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.

Experimental neurology - 1 Dec 2013

Wellman Cara L, Camp Marguerite, Jones V Morgan, MacPherson Kathryn P, Ihne Jessica, Fitzgerald Paul, Maroun Mouna, Drabant Emily, Bogdan Ryan, Hariri Ahmad R, Holmes Andrew

Abstract excerpt

Serotonin is critical for shaping the development of neural circuits regulating emotion. Pet-1 (FEV-1) is an ETS-domain transcription factor essential for differentiation and forebrain targeting of serotonin neurons. Constitutive Pet-1 knockout (KO) causes major loss of serotonin neurons and forebrain serotonin availability, and behavioral abnormalities. We phenotyped Pet-1 KO mice for fear conditioning and...

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Source

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Identifiers

PMID: 24100022
DOI: 10.1016/j.expneurol.2013.09.025
PMCID: PMC3932627

Genes

FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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