Article
Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory.
Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2012
Hartley Catherine A, McKenna Morgan C, Salman Rabia, Holmes Andrew, Casey B J, Phelps Elizabeth A, Glatt Charles E
Abstract excerpt
Growing evidence suggests serotonin's role in anxiety and depression is mediated by its effects on learned fear associations. Pharmacological and genetic manipulations of serotonin signaling in mice alter the retention of fear extinction learning, which is inversely associated with anxious temperament in mice and humans. Here, we test whether genetic variation in serotonin signaling in the form of a common human...
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