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Article

Weighted SNP set analysis in genome-wide association study.

PloS one - 1 Jan 2013

Dai Hui, Zhao Yang, Qian Cheng, Cai Min, Zhang Ruyang, Chu Minjie, Dai Juncheng, Hu Zhibin, Shen Hongbing, Chen Feng

Abstract excerpt

Genome-wide association studies (GWAS) are popular for identifying genetic variants which are associated with disease risk. Many approaches have been proposed to test multiple single nucleotide polymorphisms (SNPs) in a region simultaneously which considering disadvantages of methods in single locus association analysis. Kernel machine based SNP set analysis is more powerful than single locus analysis, which...

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PMID: 24098741
DOI: 10.1371/journal.pone.0075897
PMCID: PMC3786949

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