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Article

Association test based on SNP set: logistic kernel machine based test vs. principal component analysis.

PloS one - 1 Jan 2012

Zhao Yang, Chen Feng, Zhai Rihong, Lin Xihong, Diao Nancy, Christiani David C

Abstract excerpt

GWAS has facilitated greatly the discovery of risk SNPs associated with complex diseases. Traditional methods analyze SNP individually and are limited by low power and reproducibility since correction for multiple comparisons is necessary. Several methods have been proposed based on grouping SNPs into SNP sets using biological knowledge and/or genomic features. In this article, we compare the linear kernel...

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Identifiers

PMID: 23028716
DOI: 10.1371/journal.pone.0044978
PMCID: PMC3441747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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