Article
Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011
Valkova Christina, Albrizio Marina, Röder Ira V, Schwake Michael, Betto Romeo, Rudolf Rüdiger, Kaether Christoph
Abstract excerpt
The nicotinic acetylcholine receptor of skeletal muscle is composed of five subunits that are assembled in a stepwise manner. Quality control mechanisms ensure that only fully assembled receptors reach the cell surface. Here, we show that Rer1, a putative Golgi-ER retrieval receptor, is involved in the biogenesis of acetylcholine receptors. Rer1 is expressed in the early secretory pathway in the myoblast line...
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