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Article

Sequence variations affecting AU-rich element function and disease.

Frontiers in bioscience (Landmark edition) - 1 Jan 2012

Hitti Edward, Khabar Khalid S A

Abstract excerpt

Adenylate-uridylate rich elements (AREs) in the 3'UTRs of many transiently expressed genes regulate mRNA instability and translation. Such ARE-genes are involved in vital biological processes like cellular growth, differentiation, and immunity. Defects in their expression contribute to a variety of disease conditions like cancer, autoimmune diseases, diabetes, and cardiovascular and chronic inflammatory diseases....

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PMID: 22201840
DOI: 10.2741/4023

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