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Article

p53-dependent R-loop formation and HPV pathogenesis

23 Aug 2023

Abstract excerpt

R-loops are trimeric RNA: DNA hybrids that are important physiological regulators of transcription; however, their aberrant formation or turnover leads to genomic instability and DNA breaks. High-risk human papillomaviruses (HPV) are the causative agents of genital as well as oropharyngeal cancers and exhibit enhanced amounts of DNA breaks. The levels of R-loops were found to be increased up to 50-fold in cells...

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PMID: 37611058
DOI: 10.1073/pnas.2305907120

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