Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein.

Nucleic acids research - 15 Jul 2000

Audebert M, Radicella J P, Dizdaroglu M

Abstract excerpt

We have investigated the effect of single amino acid substitutions of conserved arginines on the catalytic activities of the human Ogg1 protein (alpha-hOgg1-Ser(326)) (wild-type alpha-hOgg1). Mutant forms of hOgg1 with mutations Arg(46)-->Gln (alpha-hOgg1-Gln(46)) and Arg(154)-->His (alpha-hOgg1-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Formamidopyrimidine Glycosylase
Share to DNA Repair
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine

Share to Kinetics

Share to N-Glycosyl Hydrolases

Share to Pyrimidines

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 10908322
DOI: 10.1093/nar/28.14.2672
PMCID: PMC102664

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10908322-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein.PMID 10908322Read ↗

Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations.Semantic proximity Read ↗

Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket.Semantic proximity Read ↗

Step-by-step mechanism of DNA damage recognition by human 8-oxoguanine DNA glycosylase.Semantic proximity Read ↗

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.Semantic proximity Read ↗

Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment.Semantic proximity Read ↗

Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.Semantic proximity Read ↗

Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.Semantic proximity Read ↗

DNA damage processing by human 8-oxoguanine-DNA glycosylase mutants with the occluded active site.Semantic proximity Read ↗

Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site.Semantic proximity Read ↗

Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA.Semantic proximity Read ↗

Genetic changes of hOGG1 and the activity of oh8Gua glycosylase in colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.