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Article

Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step.

Nucleic acids research - 15 Mar 2001

Vidal A E, Hickson I D, Boiteux S, Radicella J P

Abstract excerpt

The generation of reactive oxygen species in the cell provokes, among other lesions, the formation of 8-oxo-7,8-dihydroguanine (8-oxoG) in DNA. Due to mispairing with adenine during replication, 8-oxoG is highly mutagenic. To minimise the mutagenic potential of this oxidised purine, human cells h...

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Share to Carbon-Oxygen Lyases
Share to Deoxyribonuclease IV (Phage T4-Induced)
Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA-Formamidopyrimidine Glycosylase

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Source

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Identifiers

PMID: 11238994
DOI: 10.1093/nar/29.6.1285
PMCID: PMC29755

Genes

HAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11238994-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step.PMID 11238994Read ↗

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