Article

Overcoming Chemoresistance to Vemurafenib in Melanoma via Targeted Inhibition of PCK1 Using 3-mercaptopropionic Acid

2021-05-07

Abstract excerpt

<h4>Background: </h4> BRAF inhibitors are the mainstay treatment for melanoma with the V600E mutation, but its resistance to BRAFi remains a clinical challenge. Therefore, it is necessary to explore the mechanism of BRAFi resistance and develop new therapeutic targets. <h4>Methods: </h4>: We established an A2058 melanoma cell line with acquired resistance to vemurafenib in vitro . RNA sequencing was used to identi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c9ba6fd-ca57-545d-8780-d991adb7f4b8
DOI: 10.21203/rs.3.rs-462600/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overcoming Chemoresistance to Vemurafenib in Melanoma via Targeted Inhibition of PCK1 Using 3-mercaptopropionic AcidDOI 10.21203/rs.3.rs-462600/v1Read

3-Bromopyruvate Suppresses the Malignant Phenotype of Vemurafenib-Resistant Melanoma Cells.Semantic proximity Read

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cellsSemantic proximity Read

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors.Semantic proximity Read

ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling.Semantic proximity Read

Analysis of BRAF inhibitor resistance in melanoma cellsSemantic proximity Read

[Progress of anti-tumor study based on BRAF].Semantic proximity Read

[Silencing of PKG1 expression enhances the efficacy of vemurafenib against melanoma cell].Semantic proximity Read

Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated TumoursSemantic proximity Read

Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.Semantic proximity Read

ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations.Semantic proximity Read

Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanomaSemantic proximity Read