Article
Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization.
EMBO reports - 1 Feb 2018
Verlande Amandine, Krafčíková Michaela, Potěšil David, Trantírek Lukáš, Zdráhal Zbyněk, Elkalaf Moustafa, Trnka Jan, Souček Karel, Rauch Nora, Rauch Jens, Kolch Walter, Uldrijan Stjepan
Abstract excerpt
Altered cell metabolism is a hallmark of cancer, and targeting specific metabolic nodes is considered an attractive strategy for cancer therapy. In this study, we evaluate the effects of metabolic stressors on the deregulated ERK pathway in melanoma cells bearing activating mutations of the NRAS or BRAF oncogenes. We report that metabolic stressors promote the dimerization of KSR proteins with CRAF in NRAS-mutant...
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