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Magnetoresistive sensor for real-time single nucleotide polymorphism genotyping.

Biosensors & bioelectronics - 15 Feb 2014

Rizzi Giovanni, Westergaard Østerberg Frederik, Dufva Martin, Fougt Hansen Mikkel

Abstract excerpt

We demonstrate a magnetoresistive sensor platform that allows for the real-time detection of point mutations in DNA targets. Specifically, we detect point mutations at two sites in the human beta globin gene. For DNA detection, the present sensor technology has a detection limit of about 160 pM and a dynamic range of about two orders of magnitude. The sensors are based on a new geometry for biological sensing...

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PMID: 24094523
DOI: 10.1016/j.bios.2013.09.026

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