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Article

Spatially addressable bead-based biosensor for rapid detection of beta-thalassemia mutations.

Analytica chimica acta - 25 Jan 2010

Ng Johnson Kian-Kok, Wang Wen, Liu Wen-Tso, Chong Samuel S

Abstract excerpt

A simple glass-polymer bead-based biosensor was validated for the detection of beta-thalassemia mutations. Different bead types, each carrying allele-specific probes targeting a particular mutation on the beta-globin gene, were immobilized and distinguished on the chip based on their spatial addresses. Genomic DNA samples carrying various single nucleotide transitions and transversions in the beta-globin gene...

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Identifiers

PMID: 20103094
DOI: 10.1016/j.aca.2009.11.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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