Article
Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection.
PLoS genetics - 1 Jan 2013
Renzette Nicholas, Gibson Laura, Bhattacharjee Bornali, Fisher Donna, Schleiss Mark R, Jensen Jeffrey D, Kowalik Timothy F
Abstract excerpt
Populations of human cytomegalovirus (HCMV), a large DNA virus, are highly polymorphic in patient samples, which may allow for rapid evolution within human hosts. To understand HCMV evolution, longitudinally sampled genomic populations from the urine and plasma of 5 infants with symptomatic conge...
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