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Article

Limits and patterns of cytomegalovirus genomic diversity in humans.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015

Renzette Nicholas, Pokalyuk Cornelia, Gibson Laura, Bhattacharjee Bornali, Schleiss Mark R, Hamprecht Klaus, Yamamoto Aparecida Y, Mussi-Pinhata Marisa M, Britt William J, Jensen Jeffrey D, Kowalik Timothy F

Abstract excerpt

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congenitally infected infants. We show that there is an upper limit to HCMV genomic diversity in these patient samples, with ∼ 25% of the genome being devoid of...

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Identifiers

PMID: 26150505
DOI: 10.1073/pnas.1501880112
PMCID: PMC4522815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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