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Article

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells

18 Jun 2008

Abstract excerpt

Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGFbetaR, and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They activate many of the same signal transduction pathways. To identify the critical target genes required for transformation in hematopoietic cells, we used a comparative gene expression strategy in which selective small molecules were applied to 32Dcl3 cells that...

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PMID: 18559972
DOI: 10.1182/blood-2007-07-103010

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