Article
Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection.
Human genetics - 1 Feb 2014
Zhang Xiaoai, Xu Hongmei, Chen Xiaodan, Li Xiujun, Wang Xianjun, Ding Shujun, Zhang Renli, Liu Lijuan, He Cui, Zhuang Lu, Li Hao, Zhang Panhe, Yang Hong, Li Tingyu, Liu Wei, Cao Wuchun
Abstract excerpt
Myxovirus resistance A (MxA) is an antiviral protein induced by type I interferons α and β (IFN-α and IFN-β) that can inhibit virus replication. We examined whether the MxA polymorphisms were related to the risk and severity of enterovirus 71 (EV71) infection in Chinese populations. The MxA C-123A and G-88T polymorphisms were genotyped in two independent case-control populations in China by polymerase chain...
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