Article

Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche

2024-05-05

Abstract excerpt

Neutrophils (PMNs) reside as a marginated pool within the vasculature, ready for deployment during infection. However, how endothelial cells (ECs) control PMN extravasation and activation to strengthen tissue homeostasis remains ill-defined. Here, we found that the vascular ETS-related gene (ERG) is a generalized mechanism regulating PMN activity in preclinical tissue injury models and human patients. We show that...

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Literature Corpus work: d1e6099e-85dc-5770-b3f2-1c0325d7027f
DOI: 10.1101/2024.05.02.591799

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