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Article

Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Dec 2013

Schreiber Franziska, Szekat Christiane, Josten Michaele, Sahl Hans-Georg, Bierbaum Gabriele

Abstract excerpt

The 3' end of rsbU, encoding the positive regulator of the stress factor sigma B, was identified as a hot spot for spontaneous IS256 insertion in Staphylococcus aureus SA137/93G. Interestingly, subinhibitory concentrations of chloramphenicol in combination with heat stress, as well as linezolid and spectinomycin at physiological temperatures, selected for such rsbU::IS256 insertion mutants. In consequence of the...

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Identifiers

PMID: 24080654
DOI: 10.1128/AAC.01585-13
PMCID: PMC3837861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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