Human Polyomavirus JC monitoring and noncoding control region analysis in dynamic cohorts of individuals affected by immune-mediated diseases under treatment with biologics: an observational study.

doi:10.1186/1743-422X-10-298

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Human Polyomavirus JC monitoring and noncoding control region analysis in dynamic cohorts of individuals affected by immune-mediated diseases under treatment with biologics: an observational study.

Virology journal - 30 Sept 2013

Bellizzi Anna, Anzivino Elena, Rodio Donatella Maria, Cioccolo Sara, Scrivo Rossana, Morreale Manuela, Pontecorvo Simona, Ferrari Federica, Di Nardo Giovanni, Nencioni Lucia, Carluccio Silvia, Valesini Guido, Francia Ada, Cucchiara Salvatore, Palamara Anna Teresa, Pietropaolo Valeria

Abstract excerpt

BACKGROUND: Progressive multifocal leukoencephalopathy (PML) onset, caused by Polyomavirus JC (JCPyV) in patients affected by immune-mediated diseases during biological treatment, raised concerns about the safety profile of these agents. Therefore, the aims of this study were the JCPyV reactivation monitoring and the noncoding control region (NCCR) and viral protein 1 (VP1) analysis in patients affected by...

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PMID: 24079660
DOI: 10.1186/1743-422X-10-298
PMCID: PMC3849738

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