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Article

An analysis of polymorphisms within the Wnt signaling pathway in relation to ovarian cancer risk in a Polish population.

Molecular diagnosis & therapy - 1 Feb 2014

Mostowska Adrianna, Pawlik Piotr, Sajdak Stefan, Markowska Janina, Pawałowska Monika, Lianeri Margarita, Jagodzinski Paweł P

Abstract excerpt

BACKGROUND AND OBJECTIVE: The Wnt/β-catenin signaling pathway has been considered to be a factor in the development and progression of ovarian cancer. METHODS: All patients with ovarian cancer and controls were tested for BRCA1 mutations (5382incC, C61G, 4153delA) with HybProbe assays and for BRCA2 mutation (5946delT) using high-resolution melting curve analysis (HRM). Mutation carriers were excluded from the...

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Identifiers

PMID: 24078348
DOI: 10.1007/s40291-013-0059-y
PMCID: PMC3899496

Genes

APC
AXIN2
BRCA1
BRCA2
CTNNB1

Variants

Provenance

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