Article
DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population.
Molecular biology reports - 1 Aug 2013
Mostowska Adrianna, Sajdak Stefan, Pawlik Piotr, Lianeri Margarita, Jagodzinski Paweł P
Abstract excerpt
Studies have demonstrated that changes in DNA methylation of cancer related genes can be an elementary process accounting for ovarian tumorigenesis. Therefore, we evaluated the possible association of single nucleotide polymorphisms (SNPs) of DNA methyltransferases (DNMTs) genes, including DNMT1, DNMT3B, and DNMT3A, with ovarian cancer development in the Polish population. Using PCR-RFLP and HRM analyses, we...
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