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Article

Association of single nucleotide polymorphisms in Wnt signaling pathway genes with breast cancer in Saudi patients.

PloS one - 1 Jan 2013

Alanazi Mohammad Saud, Parine Narasimha Reddy, Shaik Jilani Purusottapatnam, Alabdulkarim Huda A, Ajaj Sana Abdulla, Khan Zahid

Abstract excerpt

Breast cancer is a complex heterogeneous disease involving genetic and epigenetic alterations in genes encoding proteins that are components of various signaling pathways. Candidate gene approach have identified association of genetic variants in the Wnt signaling pathway genes and increased susceptibility to several diseases including breast cancer. Due to the rarity of somatic mutations in key genes of Wnt...

Topics

Adult
Axin Protein
Breast Neoplasms
Female
Genotype
Glycoproteins
Humans
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Saudi Arabia

Transcription Factor 7-Like 2 Protein

Wnt Signaling Pathway

beta Catenin

Source

Open in PubMed Open full text

Identifiers

PMID: 23516639
DOI: 10.1371/journal.pone.0059555
PMCID: PMC3597615

Genes

AXIN2
DKK3
DKK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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