Article
Phosphorylation-dependent binding of a 138-kDa myc intron factor to a regulatory element in the first intron of the c-myc gene.
The Journal of biological chemistry - 15 Mar 1990
Zajac-Kaye M, Levens D
Abstract excerpt
A 138-kDa nuclear protein was identified from HeLa cell extracts as a factor which binds to a previously described 20-base pair cis element located in the intron I of the c-myc gene. This myc intron factor (MIF) binds to the wild type c-myc sequence but does not bind under similar conditions to c...
Topics
- Acid Phosphatase
- Base Sequence
- Binding Sites
- Cell Nucleus
- DNA
- Electrophoresis, Polyacrylamide Gel
- HeLa Cells
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligonucleotide Probes
- Phosphoproteins
- Phosphorylation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myc
- Regulatory Sequences, Nucleic Acid