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Article

Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer.

BMC cancer - 27 Sept 2013

Popovici Vlad, Budinska Eva, Bosman Fred T, Tejpar Sabine, Roth Arnaud D, Delorenzi Mauro

Abstract excerpt

BACKGROUND: The mutation status of the BRAF and KRAS genes has been proposed as prognostic biomarker in colorectal cancer. Of them, only the BRAF V600E mutation has been validated independently as prognostic for overall survival and survival after relapse, while the prognostic value of KRAS mutation is still unclear. We investigated the prognostic value of BRAF and KRAS mutations in various contexts defined by...

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Source

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Identifiers

PMID: 24073892
DOI: 10.1186/1471-2407-13-439
PMCID: PMC3849526

Genes

BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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