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Article

Super-Enhancer-Driven LncRNA UNC5B-AS1 Inhibits Inflammatory Phenotypic Transition in Pulmonary Artery Smooth Muscle Cells via Lactylation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2025

Zhu Xiangrui, Pang Xiangming, Wang Xiaoying, Guan Xiaoyu, Tang Yujing, Wang Zhaosi, Zhang Lixin, Zheng Xiaodong, Li Fei, Mei Jian, Ou Langlin, Liu Yuxiang, Meng Zitong, Chen Yingli, Ma Cui

Abstract excerpt

BACKGROUND: The phenotypic transition of pulmonary artery smooth muscle cells (PASMCs) is a central pathological alteration in pulmonary artery remodeling, contributing to pulmonary hypertension. Super-enhancers (SEs), characterized by histone modifications and the binding of coactivators, drive the expression of prominent genes that define cellular identity. However, the specific role of SEs, particularly...

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Share to Forkhead Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Pulmonary Artery

Share to RNA, Long Noncoding

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Source

Identifiers

PMID: 40336475
DOI: 10.1161/ATVBAHA.124.322174

Genes

UNC5B
FOXP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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