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Article

Genetic variants in interferon-λ 4 influences HCV clearance in Chinese Han population.

Scientific reports - 10 Feb 2017

Huang Peng, Yao Yinan, Yue Ming, Tian Ting, Chen Hongbo, Chen Mingzhu, Wang Jie, Zhang Yun, Yu Rongbin

Abstract excerpt

Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. To evaluate the impact and clinical usefulness of IFNL4 ss469415590 genotype on predicting both spontaneous HCV clearance and response to therapy in Chinese population, we genotyped 795 chronic HCV carriers, 460 subjects with HCV natural...

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Identifiers

PMID: 28186161
DOI: 10.1038/srep42408
PMCID: PMC5301237

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