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Article

Improved growth response of antibody/receptor chimera attained by the engineering of transmembrane domain.

Protein engineering, design & selection : PEDS - 1 Oct 2004

Kawahara Masahiro, Ogo Yuko, Ueda Hiroshi, Nagamune Teruyuki

Abstract excerpt

Structure-based design of antibody/cytokine receptor chimeras has permitted a growth signal transduction in response to non-natural ligands such as fluorescein-conjugated BSA as mimicry of cytokine-cytokine receptor systems. However, while tight on/off regulation is observed in the natural cytoki...

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Identifiers

PMID: 15548567
DOI: 10.1093/protein/gzh088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15548567-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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